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In this report, we propose a new definition of resolution for array CGH technology, termed "functional resolution," that incorporates the uniformity of element spacing on the array, as well as the sensitivity of each platform to single-copy alterations.
Importantly, at a higher functional resolution (4 EC level annotation), the gains are even more impressive (Figure 3B).
Unbiased functional resolution of genome-wide transcriptional profiles may, to this end, provide a rational basis for targeted optimization of phenotypic output [33] [35].
We analyzed the regenerative process with a high level of temporal, morphological and functional resolution, by live imaging and functional analysis of the same animals over the course of one month of regeneration.
So far, ETA annotations have been shown to be functionally specific (positive predictive values above 90%) in enzymes and non-enzymes alike [57], but their functional resolution and coverage are limited.
The specificity may be increased further at the expense of the functional resolution: at the third EC digit (Figure S1A) the accuracy remains perfect (100%) up to 29% coverage, which corresponds to a z-score of 1.7 or above, and it remains over 98% until 72.7% coverage and a z-score of 0.67 or above.
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53 For density functional calculations, resolution of the identity (RI) approximation with the auxiliary TZV/J Coulomb fitting basis sets and PBE functional were employed.
A high functional temporal resolution of about 15ms was obtained by laser scanning along one-dimensional custom-defined traces, crossing the glomeruli of interest through an arbitrary horizontal plane [ Fig. 1(a)].
In fact, the contrast medium, injected intravenously, passes through the vascular region of interest generating an enhanced ultrasound signal that allows a better morphological and functional imaging resolution [ 1].
In the current paper, Monahan and colleagues provide a comprehensive and functional high-resolution analysis of the 3D organization of olfactory-receptor-gene clusters and Greek islands during the differentiation of mouse OSNs.
Recent developments include spectrally resolved and functional super-resolution microscopy, ultrahigh-throughput single-molecule spectroscopy, interference-based microscopy for 2D materials, and uncovering the nanoscale ultrastructure of the membrane cytoskeleton and intracellular vesicles.
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