Though several recent studies indicate that SMN influences motor neuron axonal morphology [19], [20], it remains unclear whether SMN has a specific neuromuscular junction (NMJ) function, and whether the functional requirement for SMN activity is increased at the NMJ than elsewhere in the organism.
However, studies investigating the functional ablation of βIII-tubulin functions in this setting are required to demonstrate conclusively its functional requirement for the emergence of castration-resistant tumours.
In vitro and cell-based structure-function approaches reveal an unexpected functional requirement for intrinsically disordered regions within RIIα.
Importantly, we found no functional requirement for TLR2 in Treg function, as TLR2−/− Treg suppressed colitis as effectively as WT Treg.
Once we had demonstrated that the majority of Drosophila Pex proteins are required for peroxisome assembly, we next assayed the functional requirement for peroxisomes in Drosophila embryonic development by examining the developmental phenotype of flies with homozygous mutations in Pex1, because mutations in human PEX1 are the most common cause of PBD (Reuber et al., 1997; Steinberg et al., 2006).
It appears that the number of OR genes is determined primarily by the functional requirement for each species, but once the number reaches the required level, it fluctuates by random duplication and deletion of genes.
Its enzymatic production and degradation, along with its functional requirement for thiol oxidation, facilitate the specificity for time and place that are required in signaling.
The expression patterns of ILK and β1-integrin in Drosophila hearts suggest a possible functional requirement for the β1-integrin/ILK pathway in maintaining normal heart structure and function.
If he did, he would surely see that such a property is a functional requirement for highly social creatures such as us humans.
Airflow estimates taken from the flow network models are functional requirement for the system fan selection.
Here we examined the propensity and functional requirement for indels within HIV-1 bnAbs.
