In addition, it is not clear to what degree the proteoglycan content of the disc must be improved in order to influence disc function, and it may be necessary to use additional techniques to ensure functional repair.
Schwank, G. et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.
HAMC also improves the distribution, viability, and functional repair of neural stem and progenitor cells (NSCs).
Thus, in this model of SCI, tissue and functional repair is attributed to ChABC.
These bioscaffolds with strategic biomimicry have been shown to allow for integrative and functional repair of tissue injuries.
Recapitulation of the matrix structure and cellular organization in repair tissues is key to generating long-term functional repair tissue.
Keirstead, H. S., Hasan, S. J., Muir, G. D. & Steeves, J. D., Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord.
Yu, Y. et al. Use of Recombinant Human Stromal Cell Derived Factor 1α Loaded Fibrin/Hyaluronic Acid Hydrogel Networks to Achieve Functional Repair of Full‐Thickness Bovine Articular Cartilage Via Homing of Chondrogenic Progenitor Cells.
Advances in our basic understanding of peripheral nerve biology, as well as biomaterial engineering, will further improve the functional repair of myelinated peripheral nerves.
In addition, the LM/E-PA scaffold treatment significantly reduced the time required for the structural and functional repair of skeletal muscle.
Due to its limited healing potential within the inner avascular region, functional repair of the meniscus remains a significant challenge in orthopaedic surgery.
