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Of the restriction genes, TRIM5 appears to be the closest functional relative of Fv-1 [8].
Analyzing the functional relative contribution of specific domains, we noticed a higher involvement of Bacteria in the Amino acid metabolism, except for the biosynthesis of glutamate, more represented in eukaryotes.
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As well as genes within related categories, the candidate gene lists contained genes that had no known functional relatives.
Briefly, we concentrated on the SNPs with relatively high minor allele frequencies that are situated within potentially functional sites relative to known constitutive and predicted alternative exons (Table 2).
These may modulate functional versatilities, relative sizes of the jelly-roll motifs, and the specific amino acid residues involved in stabilization and folding of the active center.
By virtue of the nature of the diamidodiol used as chain extenders, the hard segments contain a greater density of hydrogen bonding –NHC =O)– functional groups relative to those prepared using traditional short chain 1,n-alkanediols.
This method places the potential disease-causing proteins in a functional context, relative to other known or unknown disease-associated proteins, and thus, systematic investigation of such complexes might unmask new candidate genes for NAFLD-related phenotypes.
Functional and relative DNA titer of viral vectors (mean ± SEM).
The positional distribution of the centers of the functional windows relative to TSS confirmed this hypothesis.
Comparing functional gene relative abundance data with the absolute abundances shown in Fig. 1, some new patterns were revealed.
Likewise, the 16 polymorphic genes were also not enriched for functional terms relative to all poly-Q encoding genes.
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