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There is still much uncertainty about the natural prevalence of DS, the dominance of possible mechanisms for DS and how/why Nature achieves evolutionary diversities and functional regulations of proteins by using 3D domain swapping.
We corrected it by adding two positive regulations from the sigma factor RpoD to ihfA and ihfB according to a recent publication on E. coli functional regulations [ 25].
The established regulatory networks from RegNetwork provide genome-wide regulatory interactions, which lay an initial foundation and establish a prior background network to identify or verify molecular and functional regulations in pathways or subnetworks corresponding to different phenotypes.
For example, the functional regulations in small domain proteins frequently arise through changes in the residue-dynamics rather than large domain movements (Dima and Thirumalai 2006; Smock and Gierasch 2009; Gerek and Ozkan 2011).
Although we take a simple Boolean network to model the genetic network, it is likely that the network topology encodes the primary constraints of the functional regulations in the cell, which is crucial to de novo prediction of phenotypic consequences for perturbations to the system.
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It is well known that Rho GTPases play a central role in the functional regulation of EC barrier function [ 35].
In this review, we describe recent advances in elucidating the functions of cortical microtubules in response to phytohormones and abiotic stresses, and their functional regulation by membrane-associated and membrane-tethered proteins and lipids.
Thereby telethonin plays an important role in myofibril assembly and in muscle development and functional regulation.
However, the functional regulation of hEAG channels by signal transduction is not fully understood.
We expect that the functional regulation of TAMs by pH-responsive nanomaterials is a promising therapeutic approach for cancer immunotherapy.
We observed monomer dimer equilibrium of this domain, which may be related to holoenzyme architecture and/or functional regulation.
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