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When the functional registration begins, the group of subjects is in anatomical alignment.
Thus, we view the functional registration algorithm as a fine-tuning of the anatomical alignment.
The functional registration algorithm modifies the time-series and spatial positions of the floating subject mesh nodes only.
This suggests that strongly imposing the preservation of internode distances may be too strict for functional registration.
In the second half of the movie, mean correlation improved from +0.068 to +0.088 with functional registration based on the P1 warp.
The alignment then proceeds by sequentially registering the remaining subjects to the group atlas using the pair-wise functional registration algorithm described above.
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For cross-validation of these functional registrations, we then applied the P2 warp to the data from the first half of the movie and vice versa and calculated the correlations again for comparison with the initial values.
The implementation of Functional Image Registration (FIRE), an operating system (OS) and platform independent multimodal image registration software is reported.
A CT scanner positioned in line with a PET scanner and with a common patient couch and operating console has provided a practical solution to anatomical and functional image registration.
We also successfully managed to use three innovative proxy indicators of death in the absence of a formal and functional vital registration system.
A fully functional civil registration system is key to achieving this and should be compulsory, universal, permanent and continuous.
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