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Our observations argue for the first mechanism, i.e. a significant functional reduction in hyperthermophiles.
Moreover, downregulation of RXFP1 may cause a functional reduction in relaxin activity in cerebral arteries during vasospasm.
The present study shows that the impairment of vesicular exocytosis of enteric varicosities in myosin deficiency is associated with functional reduction in pIJP in gastric antrum.
To show that loss of BACE1 resulted in a functional reduction in APP cleavage, levels of Aβ were measured in WT and BACE1 −/− mice cerebral cortices.
For example, Blanck et al. [ 43] demonstrated functional reduction in neurological injury following 8 minutes of CA after SEVO-induced preconditioning.
Furthermore, this lack of impact on disease phenotype appears to be due to a relative deficiency of C4 in the MRL mouse strain that results in a functional reduction in the classical pathway hemolytic activity.
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It would therefore appear that, with respect to CTRL B6 mice, CTRL MRL mice have C4 deficiency marked by functional reductions in classical pathway hemolytic activity.
In murine models, functional reductions in resistin protein (e.g., anti-resistin antibodies, resistin gene knockouts) have been demonstrated to improve insulin sensitivity as well as to decrease blood glucose (2– 4), free fatty acid (2), and triglyceride levels (2).
Heterogeneity in the lung results in the functional reduction of the lung volume and predisposes the lung to mechanical forces not encountered in normal physiology.
The disease should cause lasting functional reduction of earning ability in minimum 50% (§ 12-7).
(Russian psychiatrist, out-patient department) The criteria for evaluation of a functional reduction are more detailed in Russia, where the criteria have been operationalised (see below).
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