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The classification considers also unresolved cases: (R) general functional prediction only; (S) function unknown.
The majority of these genes are of unknown function or have a very general functional prediction (table S2).
These three missense mutations were predicted to be damaging in functional prediction by SIFT and PolyPhen2.
Based on the functional prediction, these subclades represent the proteins with different molecular functions and reaction types.
This renders accurate functional prediction as key to an enhanced understanding of biological processes (Jiang et al. 2016).
The DCN of the relevant species was used to make functional prediction for the query protein.
Our method is applied to the functional prediction of proteins in yeast (Saccharomyces cerevisiae).
Protein functional prediction, or annotation, remains an important open problem in biology [1] [23].
Two of the most popular associations used for functional prediction, are PPI and transcriptional co-expression.
Linked processes were shown to improve both the coverage and the accuracy of functional prediction methodologies.
We describe applications of the gene network for functional prediction (prediction of ribosomal biogenesis genes) and prediction of essential genes.
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