Surgically resected tumor specimens are transplanted subcutaneously into immunodeficient NOD/SCID mice, and following successful engraftment (>30% success rate expected), parts of the tumor material will be used for further passage, cryopreservation (tumor bank) and to establish ex vivo propagation of cancer cell lines for use in the functional genomics personalized shRNA screens.
These functions are met using common, customized, and personalized functional modules connected by interfaces [11].
Open-architecture products (OAPs) allow users to add personalized functional modules in an original product to meet changeable requirements for the product.
Ultimately, epigenome editing represents a much-needed tool for the advancement of functional genomics and personalized medicine.
There is much potential for editing and/or correcting gene expression in somatic cells toward a new era of functional genomics and personalized medicine.
The emerging field of mass cytometry [ 26], which combines the benefits of MS with those of flow cytometry, may also bring new insights into biomarkers of schizophrenia at the functional level, with potential personalized applications in the clinic.
Multi-functional liposomes having temperature-triggered drug release and MRI functions might engender personalized chemotherapy, providing efficient patient-optimized chemotherapy.
Johnson and colleagues (2011) selected the two SLC6A4 functional polymorphisms to personalize ondansetron in the above-mentioned study, because the serotonin transporter is the main modulator of serotonergic signaling.
New mass spectrometric approaches with at least an order of magnitude more rapid analysis of small molecules within the cell's metabolome are now paving the way towards true high-throughput metabolomics, opening new opportunities in systems biology, functional genomics, drug discovery, and personalized medicine.
Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine.
