"The biggest challenges are to figure out how to ensure biological insights and functional studies keep pace with an ever accelerating pace in our ability to generate sequence," says Claire fromer-Liggethefrom the University of Maryland School of Medicine in Baltimore.
Comparable to that of upgrade to biventricular pacing, in children with LV dysfunction after chronic RV pacing, functional improvement and reverse remodeling are reported for LV single-site pacing [ 48, 49].
These results highlight our very limited understanding of the biology of this important bacterial pathogen, as well as the need for improvements in functional annotation to keep pace with the extraordinary productivity of DNA sequencing technology.
While these techniques have faced challenges in compound identification, reproducibility and bias towards certain compound functional groups, the rapid pace of technological development in MS has sought to address many of these challenges.
Finally, in perhaps the most influential trial of this past year, amantadine, given for 4 weeks to TBI patients who were minimally conscious or in a vegetative state at 4 to 16 weeks following TBI, showed a highly significant effect on accelerating the pace of functional recovery (Giacino et al., 2012).
"Our goal is to accelerate the rate and pace of both functional and non-functional (performance, scalability, reliability, etc).
Nick worked as an engineer for several medical device companies, developing a novel motion-tracking algorithm for the world's first functional lead-less cardiac pacing system.
These findings suggest that, despite being important during arrhythmia initiation, intrinsic electrophysiological heterogeneity plays little functional role during rapid pacing and sustained arrhythmia dynamics in the healthy ventricle and thus questions the need to incorporate such detail in computational models when simulating rapid arrhythmias.
Although it is currently limited by the availability of complete genome sequence and functional genomics data, the rapid pace of technological advancements in these areas will soon overcome those limitations, and we expect this methodology to gain widespread applicability.
An exponentially growing volume of sequence data can be anticipated, yet functional interpretation does not keep pace with the amount of data produced.
