Thus, the presently "orphan" proteins are not associated with any apparent functional or subcellular location characteristics that could "hinder" them from binding with other proteins.
When the physician wants more details about contraindications, drug interactions, cautions for use or adverse effects related to a given anatomical or functional location or etiology, he may click on the corresponding VCM icon to obtain the complete information (the yellow rectangle on the right, in figure 2).
When a contraindication, drug interaction, caution for use or adverse effect is found in the drug monograph, the corresponding VCM icon is placed over the gray pictogram associated with its anatomical or functional location or etiology.
When nothing is said about a given anatomical or functional location, the corresponding pictogram is grayed.
However, when a pictogram of "Mister VCM" is gray, the physician can be certain that the monograph contains no information about the corresponding anatomical or functional location, without having to read the text.
It must be emphasised that this gray pictogram on "Mister VCM" makes explicit the absence of information related to the anatomical or functional location, e.g. a grayed kidney on the contraindication "Mister VCM" indicates that a drug has no renal contraindication.
Typical format of feature table consists of a feature key (a single word or abbreviation indicating the functional group/feature), location (position/s or boundaries of the feature in the sequence) and qualifiers (auxiliary information about a feature).
The goal is to determine the presence or location of a functional group or a specific molecular structure.
The following criteria were used to select the SNPs: functional known or potentially functional effect, location in promoter regions, minor allele frequency (MAF) over 0.1 in Caucasian populations analyzed previously, localization and distribution along the gene (including upstream and downstream regions) and low described linkage disequilibrium between candidate polymorphisms.
The highly conserved residues are identified as functional or structural based on their location relative to the protein surface or the protein core.
