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In order to fit this model, it is usual to assume that the functional observations and the parameter function of the model belong to a same finite space generated by a basis of functions.
Possibly related to these functional observations of altered presynaptic function is the observation that full-length DISC1 promotes, and C-terminally truncated DISC1 retards, transport along neuronal processes of vesicles containing a synaptic vesicle protein target (Flores et al., 2011).
Similar to these functional observations, we confirmed exacerbated reduced LV function in response to TAC along with cardiac hypertrophy and fibrosis as well as accentuated LV dilation after AngII infusion in Klf15 KO mice.
Importantly, neither protein form showed any proteinase K resistance suggesting that the functional observations are not due to a cytotoxic gain-of-function of misfolded prion (PrPSc) but rather due to direct effects of the non-misfolded proteins.
The hypothesis is based on anatomical and functional observations.
According to functional observations, the fibres of the anteromedial bundle originate most anteriorly on the femoral side and insert anteriorly and medially at the tibial attachment.
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Functional observation was performed but results showed no statistical significance.
A final functional observation that warrants attention was that 14-3-3-binding 14-3-3-binding 14-3-3-binding 14-3-3-bindingation (12).
Additionally, we did not note any basal anxiety during home-cage functional observation assessment (data not shown).
We noted no effect of the RIP::IGF-1 transgene on behavioral metrics assessed in the employed five-point functional observation battery (Table S1) (data not shown).
At the cellular level, overexpression of CLCA proteins leads to activation of calcium-dependent chloride currents (Gandhi et al., 1998; Britton et al., 2002; Elble et al., 2002; Greenwood et al., 2002), and this functional observation had caused CLCAs to be initially misidentified as calcium-activated chloride channels (CaCCs) themselves (Cunningham et al., 1995).
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