Exact(9)
We might even say that the transformation has already happened the moment we ask another to join us in creating a functional neighborhood.
Functional neighborhood diversity emerges from the multifunctionality of structures.
Another approach employs a probabilistic analysis of the functional neighborhood defined by sequence alignment bit-scores [60].
The interaction factor (IF) for a gene g i, which is to be ranked, is designed to take account of the mutation landscape in its functional neighborhood [ 19].
We then test if known selective processes, such as co-transcription, physical interaction or functional neighborhood, account for the stabilization of these clusters.
Conservation of a gene in an operon is thus a strong indication of functional neighborhood and can be used to make functional inferences (Overbeek et al. 1999; Moreno-Hagelsieb and Janga 2008).
Similar(51)
What the government calls "slums" have infinitely more potential to become functional neighborhoods than the hurried development that replaces them.
Presumably, the phenotypic clustering observed in our study is related to the clustering of functional neighborhoods of genes across chromosomes, which is even partially conserved across species (Al-Shahrour et al., 2010).
These analyses are based on the premise that functionally significant parts of the genomic sequences evolve more slowly than their non-functional neighborhood.
For example, Bernick and Cerbvero pointed out that bus stations should be within 1/4 miles from residential locations in order to create a compact and multi-functional neighborhood [4].
Our method can hence also be used, to some extent, to explore the functional network neighborhood of uncharacterized proteins.
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