Sentence examples for functional mutation from inspiring English sources

Since suboptimal DDR and DNA repair are well recognized in cancer cells, it is likely that when one DDR protein has been functionally mutated, an additional functional mutation on a different protein can result in cell death.

The possibility that the functional mutation in those aromatic accessions differs from those already described cannot be ignored.

After correction for multiple hypothesis testing, InVEx identified only PTCH1 (Patched 1) as having a significant functional mutation burden.

Ehd1 encodes a B-type response regulator, and a functional mutation is found in the GARP (maize GOLDEN2, the ARR B-class proteins from Arabidopsis, and Chlamydomonas Psr1) domain, which decreased affinity to the target DNA sequence.

Genomic herd descriptors were (1) the level of linkage disequilibrium (r2) within specific chromosome segments, and (2) the average allele frequency for single nucleotide polymorphisms in close distance to a functional mutation.

It should be noted that different accessions bearing the same name or root name, which generally indicates popular varieties, sometimes corresponded to distinct varietal types, differing in terms of aroma, functional mutation, or even assignment to a sub-population (e.g. Paw San Hmwe or Ngakywe).

The functional mutation ADH1B*47His occurred in the step from (1) to (2).

Following the anticipated mode of action of the individualised vaccines, the induction of functional mutation-specific T-cell responses, as well as their trafficking to the tumour as determined by functional immunological readouts, and TCR repertoire profiling are straightforward strategies to achieve the clinical proof-of-concept first in human trials.

The high levels of di- (H3K4me2) and tri-methylation (H3K4me3) at lysine 4 of histone H3 prompted us to test the function of histone methyltransferase Smyd3, which is downregulated by the non-functional mutation in the c-kit receptor, in hCSCs.

The specificity of functional variant prediction is defined as the probability of incorrectly classifying a non-functional mutation as a functional one.

It has been reported that LINE elements with a non-functional mutation of its reverse transcriptase gene are still able to transpose using the proteins coded by a functional LINE element [ 29, 30].