Glycoproteins of the cell surface play different roles in cell function including cell differentiation, adhesion, proliferation, morphological changes and functional modulation.
Our data also highlighted the importance of cancer cells in driving function-evoked pain and neuronal plasticity (i.e., receptor upregulation and functional modulation) by tumorigenic mediators including NGF.
Ambrosino, P. et al. Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin.
Yang, X. et al. Functional modulation of the geminivirus AL2 transcription factor and silencing suppressor by self-interaction.
Evans, J. E. et al. Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans.
Lee, K. M., Jo, S., Kim, H., Lee, J. & Park, C. S. Functional modulation of AMP-activated protein kinase by cereblon.
However, the role of sympathetic nervous system in long-term structural and functional modulation of the aortic wall is yet undefined.
The identification of a third domain in NAPRTases provides a structural basis and possible mechanism for the functional modulation of this family of enzymes by ATP.
These interactions were specific to the efficacy profile of the ligands investigated and suggest that the functional modulation of GPCRs follows structurally well-defined interaction patterns.
Instead, the data suggest a hitherto unrecognised functional modulation of the pain processing network as the mode of action of hypothalamic deep brain stimulation in cluster headache [84].
