Sentence examples for functional manifestations from inspiring English sources

Here, we propose that Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in living systems.

Despite the multitude of genetic mutations being associated with the RP phenotype, the clinical and functional manifestations of the disease remain the same: nyctalopia, visual field constriction (tunnel vision), photopsias and pigment proliferation.

These classifications may be of value in discerning probable molecular mechanisms and functional manifestations of emerging mutations and polymorphisms, providing the foundation for a family-specific predictive algorithm that may allow researchers to focus experimental effort on the most probable molecular indicators of compromised receptor function and disease mechanism.

These techniques cover the study of all the morphological, biochemical and functional manifestations of senescence at the cellular level and include protocols for population analyses and high-throughput approaches in suitable model organisms.

In a previous study reporting on the persistent arthralgia associated with CHIKV infection, 44% of patients reported a prior history of joint symptoms which made it difficult to establish the real increase in symptomatic functional manifestations [5].

It is becoming increasingly clear that although the neurological symptoms of ASD are the most striking among the behavioral and functional manifestations of affected individuals, there are many associated peripheral physiological symptoms that have often gone unnoticed/ignored and clinically unaddressed.

A functional manifestation of this property is observed in the progressive uncoupling of D2 dopamine receptors and Kir3.1/3.2 channels with repeated agonist application.

This dichotomy is widely understood to be a functional manifestation of known CNS and peripheral nervous system (PNS) barriers, in addition to the variable immunocompetence of certain CNS and PNS cells.

A reduction in NO bioavailability leads to impaired endothelium-dependent vasodilation, the functional manifestation of endothelial dysfunction [ 21].

The functional manifestation of peripheral sensitization includes novel responses to previously subthreshold stimulus intensities, increased response magnitude to suprathreshold stimuli, and increased level of ongoing discharge in the absence of externally applied stimuli (3, 5, 6).

In conclusion, the results from our investigations indicate that the functional manifestation of DCM in the STZ rat model of subchronic diabetes include early diastolic flow adaptation, systolic volume dysfunction and cardiac cycle phase dependent diminution of LV kinetics.