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This silent divergence indicates that NASP evolution has been subject to strong functional constraints maintaining essential structural features required for the protein's proper functioning.
In fibroblasts from these patients, HDL retro-endocytosis is still functional in maintaining cellular cholesterol homeostasis [113].
The positive example test-set comes from a study that identified candidate genes functional in maintaining mESCs self-renewal using a genome-wide RNAi screen [ 22].
Moreover, functional proteins maintain their functionality much better on the S-layer protein matrix in comparison when being directly attached (immobilized) to solid supports.
Even though the TV functional will maintain sharp gradients, the boundaries of the constant regions do not necessarily agree with the boundaries within the image.
The resulting constructs are functional, stably maintained under conditions where the original constructs are unstable, completely defective for conjugative transfer, and transferred via electroporation.
All these data together seem to indicate that while LPC may represent a transplantable population of committed progenitors, both LPC and HPC are functional to maintain SCs niche.
Previous studies have established that brain structural and functional networks maintain a small-world organization optimized for both high local and global efficiency of information transfer [17] [19].
► Recombinant fusion proteins were functional and maintained self-assembly capability.
Taken together, these results provide strong evidence that a caspase system is functional to maintain muscle homeostasis in C. elegans.
This indicates that the genes were not recently acquired, and that they are functional and maintained in the population by selection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com