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Particularly in conservatively treated patients, or in cases after implant removal of an exclusively posterior stabilization, consecutive disc degeneration and the associated functional losing of the spinal segment clearly represent detrimental treatment results.
Findings from follow-up studies investigating the loss of reduction and functional outcome in conservatively treated patients, and patients after implant removal of an exclusively posterior stabilized fracture segment, demonstrated significant kyphosis and functional losing, when compared to age-matched controls or earlier post-operative results, respectively [ 11- 13].
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An alternative possibility is that the smallest genes are mostly dying genes that for some reason (e.g., environmental changes) became less functional, lost their introns, and started to accumulate non-synonymous and stop-gained mutations.
These data indicate that all disease-linked truncating mutations localised upstream of the NLS are likely to be non-functional, losing their ability to translocate to the nucleus [ 9].
No mortality occurred in the optimal salinity range due to ability of oyster cells to remain functional without losing water and shrinkage through accumulation of amino acids (FAA) to offset the increasing extracellular osmotic pressure (Findley, Belisle, & Stickle, 1978).
trx mutant type II neuroblasts gradually adopt a type I neuroblast functional identity, losing the competence to generate intermediate neural progenitors (INPs) and directly generating differentiated cells.
While many of the observations made for functional roles lost are based on regional deletions, the observations made for functional roles gained are almost exclusively based on whole chromosome gains.
The structured questionnaire enquired into symptom burden, functional disability, lost productive time and QoL and willingness to pay (WTP) for adequate headache treatment.
NSA programs have led to costs that the government and public may not have anticipated: correcting functional problems, lost business to US companies, additional security costs to US individuals and businesses seeking to protect private data and the lost influence due to damaged credibility of US government and businesses.
Moreover, Salmonella typhimurium lacking functional TolC loses the ability to form biofilms [ 18].
This adaptive change might have taken place either by losing functional disordered proteins (thus existing without the functions they carry out in mesophiles) or gradually reducing their disorder content by replacing their IDPs/IDRs with ordered functional analogues.
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