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There can be a variety of reasons for the conservation of sequence (including correlations between 'distant' regions), but the importance to structure and function, and functional linkage between them, underlie such correlations.
This work suggests a mechanism regulating the RBR ligase activity of TRIAD1 and HHARI, demonstrates a novel function of cullin neddylation, and demonstrates a functional linkage between RBR and CRL E3s.
Satoyama, a traditional socio-ecological production landscape, which provided a functional linkage between paddy fields and the associated environment has lost its functions.
The functional linkage between Gag and PR provides targets for novel therapeutics to inhibit drug-resistant viruses.
If this were the case, the ubiquity of fractals also makes it more difficult to determine a functional linkage between any pair of them.
This molecular data is suggestive of a functional linkage between the microbiology of the site and the apparent natural attenuation process.
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However, the functional linkages between start-ups and port activities remains rather limited, if not entirely absent, and the impact on the functioning of the innovation ecosystem at large is not substantial.
However, fishing practices can also create functional linkages between species, even if little interaction exists in nature.
It is reasonable to assume that closely related phyletic vectors (essentially the same construct is also known as phylogenetic profile [2]) suggest co-inheritance of these genes in the evolutionary history of the involved organisms, and thus could be used to infer possible functional linkages between genes/proteins.
The functional linkages between TF and its interacting partners indicate putative gene regulations.
Analysis of linkage and synteny is a useful tool for establishing both orthology relationships and also functional linkages between genes.
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