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The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein does not operate in isolation, rather in a dynamic network of interacting components that impact its synthesis, folding, stability, intracellular location and function, referred to herein as the 'CFTR Functional Landscape (CFFL)'.
We propose a novel algorithm called FACETS that discovers an atlas of functionally unique decompositions from a PPI network, portraying alternative views of the functional landscape of the network (detailed in Section 2).
Three scenarios developed for the aggregation of multiple considerations are demonstrated with maps — based on the status quo of the "(mono -functional landscape", the "mono -functional landscape" and the "sustainable landscape".
Overall, interpreting experimental results in the light of the functional landscape paradigm considerably enhances the understanding of complex biomolecular processes.
This endogenous network forms a nonlinear stochastic dynamical system, with many stable attractors in its functional landscape.
On the other hand, because the functional landscape topographies are complicated, the native state dynamics are often difficult to interpret.
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The tenets are: paradigm of soils, scientific methodology, functional landscapes, soils as individuals, behavioral functions of soils, improving documentation, sharing pedological knowledge, reliability of information, and enhancing decision making.
Table 1 Hierarchies of site information for analyses of functional landscapes † Factor Attribute Physical property Is the abiotic system altered?
We conclude by illustrating the role for multiple conservation strategies when protecting functional landscapes for pool-breeding amphibians.
In this paper, urban functional landscapes were defined based on urban land use data produced from Pleiades images, and then landscape metrics and population density were combined to identify the urban functional zones along an urban rural gradient.
Urban functional landscapes is potential of acting as bridges between the landscape ecology and urban planning theories, providing scientific support for rational urban landscape planning and urban land use policy making.
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