Sentence examples for functional insufficiency from inspiring English sources

If the left ventricle encounters either absolute or relative functional insufficiency (called left ventricular heart failure, or left-sided heart failure), a series of compensatory reactions are initiated that may temporarily provide a return to sufficient ventricular function.

Main advances in our understanding of human TDS have arisen from studies of germ cell neoplasia in situ (GCNIS), cells with features of transformed gonocytes which failed to differentiate, most likely due to a functional insufficiency of the somatic niche during fetal development.

Therefore, reduced PTEN-mTOR signaling followed by AMPK inhibition may relieve Parkinson's symptoms caused by the functional insufficiency of DA neurons.

However, for most of the patients the genetic cause of hypoplasia or at least functional insufficiency of the pituitary gland remains to be discovered.

Our current observations consistently show that SDHD-G12S and SDHD-H50R, as well as SDHD knockdown, lead to functional insufficiency of SDH and increased stability of HIF-1α in thyroid cancer cell lines.

It is well documented that ethanol leads to severe organ damage in the liver but pancreatic morphology changes are milder; rather than chronic pancreatitis only mild functional insufficiency develops in most cases.

The reprogrammed cells retained the disease genotype of the adult cells and were stimulated to differentiate into motor neurons that displayed functional insufficiencies associated with spinal muscular atrophy.

The protocol addressed pulmonary dysfunction, muscle weakness, and functional insufficiencies in the surgical population [ 23- 25].

Fyn kinase, which is said to have key role in promoting Nrf2 degradation, has been implicated in oxidative stress-associated functional insufficiencies as well as apoptosis.

Indeed, mistranslated proteins are folding substrates of HSPs and CLIPS and their continuous synthesis and accumulation in the cell likely creates chaperones functional insufficiencies that remodel their interaction networks by deviating client substrates.

In accordance with the role of Akt in cell survival pathway, the data suggest that inhibition of Akt undermines antioxidant defense mechanisms, which thus exacerbate free radical accumulation and related functional insufficiencies culminating in cell toxicity.