Are there structural features that make a fold amenable to functional innovation (innovability)?
Duplicated genes contribute to functional innovation, with the redundant duplicate often acquiring new functions that derive from an existing secondary function (Conant and Wolfe 2008).
The predictability of molecular evolution during functional innovation.
Morphological functional innovation is a method combined with functional innovation and morphological chart.
Gene circuits are a functional innovation in synthetic biology for engineering cellular behavior.
Strategies such as binary patterning or modular assembly can efficiently speed structural and functional innovation.
Mutations in proteins allow functional innovation, but can be critically destabilizing.
The evolution of gnathostome jaws, along with bite forces that can capture and masticate active prey is a key functional innovation underlying the diversification of early Devonian vertebrates1.
Statistical evidence was found to confirm only functional innovation as one of the dimensions of design innovation that fully mediates the relationship between brand distinctiveness and brand performance.
While standard today, setting aside a dedicated channel for the building's infrastructure was an important functional innovation, one that would lead Kahn to make such segregated "served" and "servant" spaces a hallmark of his designs.
However, as a Zelda game it still feels very generic to me and lacks a lot of the focus and functional innovation in the games listed above.
