For a given species the majority of functional information is typically transferred from Arabidopsis thaliana orthologs identified by sequence similarity searches.
As a result, functional information for these transferred genes may be inferred by comparing them with the related or analogous genes.
The most common approach in computational prediction of protein function is to use sequence or structure similarity to transfer functional information between proteins [2].
A COG group consists of individual orthologous proteins which typically have the same function, allowing transfer of functional information from one member to an entire COG [25].
Orthology lends the legitimacy to transfer functional information from an experimentally characterized protein to an uncharacterized one [ 18, 19].
However, it is also possible to transfer functional information based on similar phenotypes, as shown in Groth et al. (2008).
We consider further research is necessary in order to address the importance of clinical record as a valid instrument to transfer functional information through different doctors, therefore reducing the inaccuracy of functional knowledge we have found in the ED setting.
Functional annotation is normally done by transferring functional information across organisms using comparative analysis.
Many cellular processes involve more than one level of information processing, such as in the cases of signaling cascades, hubs of regulatory information transfer and functional associations.
