Ekwall, K., Olsson, T., Turner, B. M., Cranston, G. & Allshire, R. C. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres.
The upregulation of endothelial adhesion molecule expression persists after the ischemic event itself has resolved and therefore may provide a functional imprint of a prior ischemic insult [69].
Giannoukakis, N., Deal, C., Paquette, J., Kukuvitis, A. & Polychronakos, C. Polymorphic functional imprinting of the human IGF2 gene among individuals, in blood cells, is associated with H19 expression.
This may have implications for when different opportunistic infections occur, and a better understanding of the mechanisms for functional imprinting of antigen-specific T cells may lead to improvements in design of vaccines against HIV and opportunistic pathogens.
Therefore, the effect of ZFP57 on DMRs during oocyte growth is key to functional imprinting.
Thus, accelerated methylation imprints during oocyte growth cannot serve as functional imprinting in embryogenesis, with the exception of Igf2r DMR.
The latter include epigenetic mechanisms such as functional imprinting and nonepigenetic mechanisms such as familial behavioral and cultural effects.
We determine whether the accelerated methylation imprints during oocyte growth contribute to functional imprinting in embryogenesis, i.e. can regulate imprinted expression.
In conclusion, a sufficient amount of DNMT3A/DNMT3L and a shift from the resistant to permissive state are essential to establish oocyte-specific methylation imprints and that maintenance of the acquired DNA methylation imprints is essential for functional imprinting.
To understand the mechanisms of functional genomic imprinting and to elucidate the etiology of maternal hypomethylation syndrome, we must investigate histone modification or chromatin structure in oocytes.
In one study, 3-thiophene acetic acid (TAA) was used as a functional monomer to imprint an atrazine herbicide owing to its ability to hydrogen bond to this template [ 126, 127].
