Sentence examples for functional importance in the regulation of from inspiring English sources

In this study we demonstrate that the methylation state of CpG dinucleotides in the Ucp1 enhancer exhibits position-specific and adipose tissue-specific patterns in both cell lines and murine adipose tissue and that promoter methylation has functional importance in the regulation of Ucp1 expression.

Whilst hypoxia and the HIF/hydroxylase pathway in the regulation of myeloid cell function and survival is of direct functional importance in regulation of innate immune responses, a role for HIF in the regulation of heritable macrophage resistance to intracellular pathogens would clearly be important for an individual's overall disease risk.

In addition, mutation of the remaining mapped sites has not revealed any functional importance in regulation of Cdc24.

In conclusion, we demonstrate that CpG methylation of the Ucp1 enhancer exhibits CpG-position and tissue-specific patterns and, using cell lines, that this difference may have functional importance suggesting that the regulation of Ucp1 expression involves chromatin modification.

These activities of sirtuins are particularly interesting because of their importance in the regulation of aging.

Such cascades could be of considerable importance in the regulation of many processes.

A higher evolutionary conservation of the elements found in the proximity of exonic flanks compared to the background sequences would be an important indicator of their functional importance in splicing regulation [ 10, 14].

The CTCF anchor regions we identified are conserved across species, influence gene expression, and are a frequent site of mutations in cancer cells, underscoring their functional importance in cellular regulation.

The functional importance of Myc in the regulation of ICAD transcription was also demonstrated by knock-down of c-Myc and N-Myc gene expression, as well as their ectopic expression.

To probe the functional importance of temporal regulation of piRNA target genes, we first analyzed annotated functions for the 169 predicted target genes using DAVID.

Our results also highlight the functional importance of post-transcriptional regulation of gene expression during transmission of the malaria parasite between hosts.