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These interaction motifs (PDZ ligands) are found among highly conserved sequences in the intracellular domain of MHCI, and mutating specific residues in these motifs will determine their functional importance for potential interactions with known regulators of NMDA receptor function and synaptic transmission.
Eighteen morphological traits of functional importance for interactions between workers and the environment were measured to characterize the size and shape of the workers.
These rules were based on: the target residue belonging to a topological neighbourhood of the antigen in the structure of the complex between antibody and antigen; its absence of functional importance for the interaction with the antigen; and its solvent accessibility in the structure of the free antibody.
These data suggest that parkin is of functional importance for selective loss of dopamingeric neurons and the onset of PD in aged mice.
The most central ones are presumed to be of functional importance for the specific network.
The higher stability of the hexameric form under various conditions as well as resistance to limited proteolysis suggests functional importance for the oligomeric MtbMfd (Fig. 6).
This result suggests continued functional importance for these regions in all four species, yet in spite of this sensitivity, no candidate regions were identified for possible L1 mediated function.
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Our results demonstrate the functional importance of TADs for orchestrating gene expression via genome architecture and indicate criteria for predicting the pathogenicity of human structural variants, particularly in non-coding regions of the human genome.
Evolutionary conservation is only one indication of functional importance and for Ser14 there is additional evidence.
Some other genes are also demethylated, e.g., uPA (Pulukuri et al. 2007; Patra and Bettuzzi 2007), heparanase (Ogishima et al. 2005), and clusterin (Rauhala et al. 2008) which may have functional importance, especially for the invasive phenotype.
This suggests that the amino acid sequence of the uORF peptide does not have a functional importance not only for AtMHX[ 15, 16] but also for the expression of other MHX genes.
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