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Functional implications on the sister enzyme FamD2 are also discussed.
Given that stromal cathepsin D expression is observed in a broad spectrum of tumors, we addressed its possible functional implications on tumor cell behavior.
Our results are in line with similar studies from other groups that demonstrate functional implications on differentiation potential [10], [11], [34], [37].
In this study, we demonstrate that replicative senescence of MSC has functional implications on surface marker expression and differentiation potential and that it evokes consistent changes in the global gene expression and miRNA expression profiles of MSCs from different donors.
Functional implications on STAT3 mediated leptin signalling of the detected variants were analyzed in vitro.
Next, we addressed the issue whether Th17 have any functional implications on HNSCC development and HNSCC milieu.
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We have focused on the functional implications of applied currents during sleep on sleep-dependent memory consolidation [2], [9] as well as on the state dependence of these effects [5].
Discussion on functional implications of tooth structure.
To study the structural and functional implications of these mutations on RING2-REP domain of Parkin, we studied the solvent accessibility (SASA/RSA), hydrophobicity, intra-molecular hydrogen bonding profile and domain analysis by various computational tools.
The functional implications of this effect on the PEG11 protein are unclear as the antisense miRNA generally do not correspond with the known retrotransposon-like domains or other structural features.
We synthesize data to speculate on the functional implications of key features of Karyorelictea including the presence of at least two macronuclei in each cell and the inability for macronuclei to divide.
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