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The aim of the present experiments both applying an anodal current oscillating at theta frequency (theta-tDCS) during either Non-REM or REM sleep is to determine firstly, the impact of ongoing brain electric activity and brain state on the ability to modulate EEG activity by weak electric currents, and secondly to determine the functional implication on memory consolidation.
In conclusion, our data indicate that BMDM density during in vitro differentiation can have a functional implication on the final macrophage populations, at least in BMDMs derived from C57BL/6 strain of mice.
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Since the advance of next-generation sequencing (NGS) technologies, the number of single nucleotide polymorphisms (SNPs) keeps increasing precipitously and it becomes crucial issue to discovering functional implication of SNPs on the biological process and complex diseases.
The functional implication of Hmt1 binding on tRNA biogenesis is supported by the observation that binding of Hmt1 at these tRNA genes correlates with their abundance levels within a cell.
As, indeed, we cannot offer much more than speculations on the functional implication of these binding sites, we have moved Figure 4G to the supplementary information.
Nevertheless, in vitro studies are needed to determine the functional implication of those genetic polymorphisms on the alteration of IGF-1 expression.
Such a relationship would provide additional evidence on a functional implication of the isochores, supporting that they are mainly a product of evolutionary adaptation [ 2, 4], rather than a simple by-product of neutral evolutionary processes [ 9- 11].
The functional implication of the cellular colocalization demonstrated on the histologic sections was examined by in vitro studies in which cultured human fetal cardiac fibroblasts, exposed to supernatants obtained from macrophages incubated with opsonized apoptotic cardiocytes, markedly increased the expression of the myofibroblast marker smooth muscle actin (scarring phenotype) [ 14].
Functional implications on the sister enzyme FamD2 are also discussed.
Given that stromal cathepsin D expression is observed in a broad spectrum of tumors, we addressed its possible functional implications on tumor cell behavior.
Our results are in line with similar studies from other groups that demonstrate functional implications on differentiation potential [10], [11], [34], [37].
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