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This progressive disconnection must be analysed in detail given the functional implication for the spatial segregation of synaptic connections implicated in the type of information transmitted.
The functional implication for the incorporation of actin into these virus particles remains unclear.
The absence of the N-terminal domain in a majority of plant POP-like proteins is intriguing since it is likely to have a functional implication for these proteins.
Reviewer #3: In the manuscript entitled "KPNB1 mediates PER/CRY nuclear translocation and circadian clock function" by Lee et al., the authors investigate the role of KPNB1 (Importin β subunit) for nuclear translocation of PER proteins and its functional implication for circadian clock oscillation in mammalian cells and flies.
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Structural consequences of this quaternary polymorphism, as well as its functional implications for helicase activity, are discussed.
The current knowledge about the functional organization of this network, its pharmacology and functional implications for human motor control are discussed in detail.
The requisite information for understanding the design and operation principles of these microsystems as well as their functional implications for optical networking is provided.
Such genetic diversity has functional implications for the immune response to viruses and generates population-based variations in HLA class I allele frequencies and KIR gene profiles.
The conformational flexibility of the N-HEAT region may provide significant functional implications, for example, adopting different conformations for the interactions with various mTOR regulators (Kim et al., 2008; Wullschleger et al., 2006; Zoncu et al., 2011).
Root architecture has important functional implications for the timing and extent of soil water extraction, yet selection for root traits in wheat breeding programs has been largely limited due to the lack of suitable phenotyping methods.
It is not inconceivable that these alterations of the IL-1 and TNF receptors may have important functional implications for the development of hyperresponsiveness in inflammatory airway diseases like asthma.
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