The initial functional description of the imperfections consists of an axisymmetric portion and a deviant portion, which are availed in the form of a double Fourier series.
In spite of the known facts that repeat variation of microsatellite loci is critical for their maintenance in the genome and in some cases may have functional consequences, our understanding of motif imperfection in microsatellites is very limited.
Moreover, in A. gambiae genome, numerous protein-coding genes harbour mutation in microsatellite sequences within the respective genes (Supplementary Table S9), indicating that motif imperfection of microsatellites may have extensive functional consequences in A. gambiae.
Despite the imperfections, the pieces are structurally sound and functional.
We examined this question by comparing the overall distribution of phylogenetic imperfection scores across the genome for various functional classes of windows, with class defined by the sequence context of the central SNP in the window.
52, 53 Measurements of resting-state functional connectivity are also subject to their own biases and imperfections.
We then considered whether the imperfection statistic might be a useful predictor of DNA functional context, such as whether a SNP occurs in coding DNA versus extragenic.
This paper presents a novel methodology to restore the designed functional properties of hypoid gear sets whose teeth deviate from their theoretical models due to inevitable imperfections in the machining process.
PCO optical imperfections cause several light reflection, refraction, and diffraction phenomena, which may interfere with the functional and structural tests performed in different ocular locations for the diagnosis and follow-up of ocular disease, like macular and optic nerve diseases.
For all its imperfections, the UN is the sole international institution of indisputable legitimacy; it has to become the functional center for harmonizing mankind's response to a threat far more insidious than any faced in history.
