Sentence examples for functional impacts on from inspiring English sources
Some appear to have major functional impacts on the organism, others may have become fixed (uniformly present in descendant lineages) solely due to morphogenetic constraints.
Villeneuve et al. demonstrated that 36% of patients with COPD, compared with 12% of healthy subjects, had mild cognitive impairment, which refers to significant cognitive decline without major functional impacts on activities of daily living.
The highest correlation between the average pathway deregulation score and the overlap mutations between DNA and RNA suggested that the conserved mutations have more functional impacts on pathway regulation and network interaction.
Considering the SNPs may have functional impacts on gene expression, the expression Quantitative Trait Loci (eQTL) approach has been proposed and commonly used to facilitate the identification of associations between intergenic SNPs and traits [ 18- 20].
We next used snpEff [ 13] version 2.0.5 in combination with GATK VariantAnnotator Broad Institutee, Cambridge MA, USA), both with default parameters, to identify the different functional impacts on coding genes.
Motivated by Akavia et al.[ 12], we considered each gene in an altered region a potential driver; its functional impacts on other genes can then be due to its direct copy number alterations or indirectly via the corresponding expression of the gene.
Syk has several interacting signaling partners e.g. Vav, the phophoinositide-specific phospholipase C PLCC) isozymes PLCγ-1 and PLCγ-2, and Cbl which are known to exert a functional impact on different leukocyte functions including cell migration [10] [17].
Polymorphisms having a functional impact on gene expression can function as markers for more complex processes underlying individual differences in reaction to family adversity, and therefore provide us with clues on possible underlying mechanisms.
The functional impact on occupational or other important areas is one of the diagnostic criteria of DSPS.
Dr. Barr testified that he did not believe that Mr. Jon's intelligence had a "functional impact" on his life.
This first set of data shows that the LDTg is activated by stress, and that its remote chemogenetic inhibition has a functional impact on VTA DA neurons activity.
