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Further, they could see "functional imbalances" between the populations.
The researchers "found that very similar functional imbalances observed in different diseases may in fact be driven by completely different set of species".
The system, created by researchers at the University of Washington, can "reveal how much different bacterial species contribute to disease-associated functional imbalances in the microbiome".
Functional imbalances, e.g., in force generation, might represent a unifying mechanism triggering a common pathological pathway in FHC for different mutations, despite variable primary functional effects [ 28, 37].
This illustrates well that the metaproteomic approach is a powerful tool for highlighting functional imbalances even in the absence of clear major shifts in the dominant bacterial groups or species.
Two clinical ramifications of these findings are 1) the net gain in function of the injured muscle unit may reflect the strengthening of the injured musculature, but the progressive weakening of the synergists and 2) physical rehabilitation may mitigate secondary joint complications that arise from chronic synergist muscle functional imbalances [ 43, 44].
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5 Be "foot aware": if you suffer from knee, hip or back pain, a small structural or functional imbalance in the foot could be to blame.
"This method allows us to pinpoint which microbial species in our microbiome are responsible for each functional imbalance so they can be targeted for therapy," said Elhanan Borenstein, an associate professor of genome sciences.
Amblyopia is one of the most common forms of visual impairment, arising from an early functional imbalance between the two eyes.
These findings support the contention that functional imbalance of the temporal cortex, perhaps mediated by CCK-4, is involved in panic disorder (PD).
Here, we demonstrated that this low yield was caused by a serious functional imbalance between MCR-C and MCR-N proteins, responsible for the two-step reduction of malonyl-CoA to 3HP.
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