Our hypothesis was that functional ID may be a prevalent condition in patients with COPD.
Patients receive an immediately functional ID and password (in the feasibility study, on a postcard with logon instructions from recruiting RNs).
Of the 409 iron-deficient patients in whom serum ferritin levels were available additionally to TSAT, 335 (81.9%) presented with functional ID (FID) (TSAT < 20%, serum ferritin ≥30 ng/ml) and 74 (18.1%) with absolute ID.
Measuring sTfR may provide more specific information, and it has the advantage over sF in that it can distinguish IDA from anaemia of chronic inflammation, as well as identify Fe depletion and functional ID in patients with concurrent inflammation.
ID can present as absolute ID (AID; depleted iron stores, serum ferritin <30 ng/ml) [ 7] or functional ID (FID) that is characterized by iron sequestration and thus, a lack of biologically available iron [transferrin saturation (TSAT) <20%], despite normal iron stores [ 8].
In addition, ID‐induced thrombocytosis resolves upon iron replacement even in patients receiving erythropoiesis stimulating agents 3. Indeed, several authors speculate that EPO‐induced thrombocytosis is caused by functional ID rather than by a direct effect of EPO on megakaryopoiesis 3. Whether elevated platelet counts predispose to thromboembolic complications has not been firmly established.
Adult anaemic cancer patients with active malignancy and absolute or functional ID (indicated by laboratory values or symptoms such as fatigue and impaired physical function) who received FCM as i.v. iron treatment in haematology and oncology practices across Germany and provided informed consent were registered to this prospective, non-interventional study.
These functional gene IDs are designated with numbers in both the tables and within the phylogenetic trees.
We assigned gene identifiers that include references to both function and the cultivar (PN, CS, or Gw) from which the gene was isolated (see Functional Gene ID in Table 1, Table 2, Table 3, and Table 4).
The search option (http://mcg.ustc.edu.cn/sdap1/follicle/follado.php) provides an interface for querying the Follicle Online database with one or more keywords such as genes/proteins names, UniProt ID or Follicle Online ID, functional stage and function etc.
