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The results presented here would provide a basis for the design and synthesis of new and functional host molecules exhibiting specific anion recognition.
In vivo, the multi-layered bioactive collagen-fibrin scaffolds loaded with the IGF-1 variant triggered dose-dependent functional host smooth muscle cell invasion and bundle formation with re-urothelialization 4 weeks after surgery in a rat model.
A more thorough understanding of these issues will logically influence the design of next generation biomaterials and the development of regenerative medicine strategies for the formation of functional host tissues.
Our previous work demonstrated that functional host cell P-gp is required for normal parasite replication [11].
The ex vivo valve model also has limitations, including the absence of a fully functional host defense system.
There are many examples of domestication of TE proteins into functional host proteins, especially the transposases [6], [7].
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Rather, systems-level analyses enable a panoramic view of the functional host-pathogen interplay, complementing significantly the traditional reductionism-dominant research (Walduck et al., 2004).
In order to assign statistical significance of the functional host-target similarities in our network, we compared the average similarity of each host to all of its targets against 100.000 randomized networks.
Possibly a co-functional host homologue, such as a RecB protein, fulfils this role in CRISPR systems lacking Cas4.
Highly conserved sites in proteins usually have important and sequence-specific functions, and, therefore, any deletion that removes the intein sequence would have to be very precise or it would result in a non-functional host gene.
Our study provided comprehensive and convincing evidence that the genes of small circular ssDNA viruses have been transferred into a broad range of eukaryotic genomes, and some of the transferred genes were also conserved and functional in host genomes.
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