Sentence examples for functional homing from inspiring English sources
The double role of the ORF and ribozyme core regions suggests that these nucleotides must be under strong selective pressure to maintain the catalytic RNA functions and to preserve the genetic code for a functional homing endonuclease.
A functional homing endonuclease gene or a mRNA transcript has been suggested for intercellular intron migration [ 25, 35].
Recent analyses of these parasitic elements with functional homing endonucleases suggest that this model in its most simple form is not always applicable.
In this model, horizontal transmission into an intronless site is promoted by a functional homing endonuclease, followed by endonuclease degradation, and eventually, intron loss.
By analyzing cybrids that combine intron-containing and intron-lacking parents, one should be able to test the hypothesis that the angiosperm cox1 intron encodes a functional homing endonuclease, assess rates of intron colonization, and measure lengths of exonic CCTs.
In agreement with this prediction many yeast VMA inteins have been shown to have non-functional homing endonucleases [ 9].
One of the two introns encodes a functional HNH homing endonuclease, suggesting endonuclease-mediated transposition [ 45].
Perturbations in CD8+ T-cell maturation have been shown for HIV-specific CD8+ T cells, in which there is an accumulation of preterminally differentiated CD45RA-CD62L- CD45RA-CD62L-[ 12, 16], and suCD8+ lack of differenTiation may result in funcellsal or homing defects.
Furthermore, it may help biologists and chemists for the design and discovery of covalent chemical probes or inhibitors homing at functional cysteine of critical protein targets implicated in various physiological or disease process.
If a backpack is attached to a cell that normally performs a useful function, such as homing to solid tumors or areas of trauma, then these native behaviors can be leveraged to deliver functional materials contained within the backpack.
The receptor for SCF, c-Kit tyrosine kinase plays a key role in hematopoietic stem cell and mast cell survival, mitogenesis, proliferation, differentiation, adhesion, homing, migration, and functional activation.
