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In this work, a model peptide (KFFCCQ) was developed to evaluate peptide coatings adhered to fibrous surfaces with multiple functional handles, i.e. the presence of a sulfur atom in cysteine and an aromatic ring in phenylalanine, to predict the durability of PNA coatings on 50/50 nylon/cotton blends (NyCo), which are commonly used in clothing such as combat and medical attire.
Many compounds underwent further elaborations at the functional handles included with the carboxylic acid building blocks.
Furfuryl and propargyl groups were included to act as functional handles for future modifications, if desired.
Two functional handles were incorporated to the parent BCP: biotin for modular postfunctionalization and 4-bromostyrene (BrS) for cross-linking.
The triazine based molecule was synthesized by treating cyanuric chloride with amines containing alkyne, amine, and maleimide functional handles.
The ability to form fragmenting hybrids from a variety of primary and secondary amines is significant because most of the agents currently used in malaria combination therapies possess such functional handles.
Similar(53)
We find ourselves "playing" with smartphones in a way we never did with the functional handle of a traditional landline phone because, whereas the first phone was designed by engineers thinking in functional terms, the phones in our pockets nowadays are always built in dialogue with marketers who have carefully noted how colour and curve, brightness and texture, heft and size make us feel.
In order to develop affinity-based biosensor platforms, appropriate ligands with a functional handle for immobilization onto a biosensor surface are required.
The polymers used for nanoparticle stabilization are carefully designed for this purpose and are synthesized by the RAFT polymerization process, as the thiocarbonylthio end group provides a functional handle for anchoring the polymers to the gold surface.
The peptoid residue linker provides a synthetically facile means of incorporating an alkyne functional handle.
The use of diester 14 allowed for the introduction of a second ester as a functional handle, providing 5-carboxy-carbofluorescein derivative 16 as a single regioisomer bearing orthogonal protecting groups on the upper and lower portions of the molecule.
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