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Centromere identity is regulated epigenetically by deposition of the centromere-specific histone H3 variant CenH3 that, being exclusively found at centromeres, constitutes the structural and functional foundation for kinetochore assembly and function [1], [2], [3], [4], [5], [6], [7], [8].
We have demonstrated that CENP-A is both a structural and a functional foundation for kinetochore formation.
The HiVe Writer forms the functional foundation for the ambitious HiVe (Hierarchical Verification Environment) project which aims to provide a unified framework in which entire design projects can be described with the highest level of assurance.
Centromeric (CEN) chromatin is embedded in heterochromatin and contains blocks of histone H3 nucleosomes interspersed with blocks of CENP-A nucleosomes, the histone H3 variant that provides a structural and functional foundation for the kinetochore.
Being raised by her Dominican mother and Persian father provided Roxana a global perspective on the meaning of wellness, and as a Health Coach, Roxana maintains a passion for the prevention of chronic diseases and the creation of a personalized, functional foundation for wellness.
CenH3-chromatin constitutes the physical and functional foundation for kinetochore assembly.
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These data lay the foundation for addressing how functional selectivity is generated from a generic ionic signal.
Our data provide the molecular basis underlying CRTC1-MAML2 oncogenic functions and lay a foundation for further functional investigation of CRTC1-MAML2-induced signaling in MEC initiation and maintenance.
To identify putative targets and to provide a foundation for functional analyses, we performed IPA function and pathway analysis for their targets.
This laid the foundation for functional genomics, genomics medicine, bioinformatics and systems biology to investigate functions and regulatory mechanisms.
Springer, N. M. et al. The maize W22 genome provides a foundation for functional genomics and transposon biology.
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