Sentence examples for functional export from inspiring English sources

Whether functional export signals are generally found in misfolded proteins is not known.

Our data show that the functional export signal in misfolded CPY contributes to ER stress tolerance by allowing it to use the vacuolar pathway.

To provide a convenient means for preparing publication-quality figures, we have developed a fully functional export module for schematic diagrams.

Each CRM1 cargo contains multiple sequences that match NES consensus patterns but most of these sequences are not functional export signals.

It may turn out that a Rev dimer or tetramer on the RRE is sufficient to recruit the Crm1 dimer that is the functional export complex.

This assay is based on the manipulation of the Rev protein shuttling cycle, and tests for the ability of functional nuclear export sequences to promote the nuclear export activity of the Rev(1.4 -GFP fusion protein, which is composed of a NES-deficient mutant of the HIV-1.4 -GFPotein and Gfusion

Thus, the presence of functional ER export signals makes a retrieval mechanism essential for the ERAD of molecules bearing them.

This finding provides a physiological basis for the existence of functional ER export signals in misfolded proteins.

IRF-5 possesses a functional nuclear export signal (NES) that controls dynamic shuttling between the cytoplasm and the nucleus.

These data show that the potential toxicity of misfolded CPY is mitigated by a functional ER export signal in the unfolded molecule.

In summary, our studies using the classical ERAD model substrate CPY* show that functional ER export signals coexist with ERAD/retention signals.