These findings suggest that RIC may have functional effects on myocardial contractile function [ 1].
Notwithstanding the wide distribution of VDR and CYP27B1, 1α,25- OH 2 D3 shows highly tissue-specific functional effects on hormone secretion, immune function, cell differentiation and growth.
Next, we tested whether LPA (18 1 unless otherwise stated) has functional effects on glomus cells using Fura 2 calcium imaging.
Building on this, we tested whether common LPA species present in blood (16:0, 18 1, and 18 2) have functional effects on the carotid body output using an en bloc perfused carotid body preparation (Fig. 1c 33,38.
Together, these results show granulocytes do not act as an intermediate to inhibit cDC1 differentiation and the functional effects on antigen specific CD8+ T cells and tumor control are primarily mediated by cDC1s, not granulocytes, in this model.
To our knowledge, this study is the first to demonstrate that miRNA mediation has functional effects on tissue-engineered constructs.
If SNPs exert functional effects on phenotypic traits, they are most likely located in intra-genic regions.
These results suggest that loss of TβRIII expression during multiple myeloma progression contributes to disease progression through its functional effects on increased cell growth, proliferation, motility, and adhesion.
Failure to promote endocytosis could have varying functional effects on receptor-mediated signal transduction.
Anti-CD137 ligand antibodies which can also crosslink CD137 ligand had the same functional effects on MM cell lines.
We propose that alterations in mitochondrial connectivity in this system are secondary to functional effects on mitochondrial membrane potential.
