Sentence examples for functional effects for from inspiring English sources

"Topiramate hits quite a lot of targets and has complex side effects, while the doses needed for functional effects for cimetidine seemed high," he cautions.

Both the silk sling and tissue engineered sling showed convincing functional effects for the treatment of stress urinary incontinence in a rat model.

The objective of this study was to examine whether this sensitivity is due to a central pharmacokinetic (i.e., higher occupancy for a given plasma level) or pharmacodynamic (i.e., greater functional effects for a given occupancy) effect.

We utilized in silico algorithms to predict likely functional effects for associated SNPs.

The positive correlation between mutations that affected neurotransmitter release in mammalian cells [29] and in C. elegans indicates these mutations have similar functional effects for both orthologous proteins.

In this study, the reciprocal coupling residues from the SCA calculation were mapped onto the Pak1 structure to illustrate their relative positions, and to identify possible interactions and functional effects for these residues.

However, since there was little evidence for functional effect for the SNPs analysed, based on bioinformatics analysis, the prior probability of 0.01 was also taken into consideration.

Available crystal data, however, do not allow us to infer any functional effect for these mutations, as well as for unclassified variants affecting residues in this domain (Ile784, Gln977, and Ser1000) or at the C-terminus (Arg1131, Leu1140, and Thr1257).

The common polymorphism, ATMex39 5557G>A (D1853N), has been reported in the homozygous state to associate with enhanced clinical radiosensitivity in breast cancer patients [ 13], suggesting that it might be considered as a risk factor predisposing to adverse reactions after radiotherapy and supporting a possible functional effect for this variant.

The evaluation module produces predictions for functional effects of SNP to protein function for non-synonymous coding SNPs, using four prediction tools: PolyPhen [11], PolyPhen-2 [12], SNPs3D [13] and SIFT [14].

First evidence for functional effects of ANP on EDS cells was obtained in current clamp experiments.