In the vast majority of mutations, there is no functional effect on the influenza virus itself.
Adzhubei, I., Jordan, D. M., & Sunyaev, S. R. Predicting functional effect of human missense mutations using PolyPhen‐2.
Adzhubei, I., Jordan, D. M. & Sunyaev, S. R. Predicting functional effect of human missense mutations using PolyPhen-2.
Backenroth, D. et al. Tissue-specific functional effect prediction of genetic variation and applications to complex trait genetics.
These data suggest that a substantial percentage of the ~10% SNVs observed in CRC may have a deleterious functional effect.
In the last column, novel driver genes are classified as 'tumor suppressor' or 'oncogene' based on the predominant functional effect of the observed mutations.
RMA-corrected predictions of functional effect were obtained with SIFT, PolyPhen-2, and PROVEAN standalone tools and compared with dbNSFP v2.9 for consistency.
(ii) Mutations with an obvious functional effect on a cancer gene but in a tumor type with no known association to that gene.
Choi, Y., Sims, G. E., Murphy, S., Miller, J. R. & Chan, A. P. Predicting the functional effect of amino acid substitutions and indels.
ACh also has a demonstrated functional effect in visual cortex that is both diverse and profound.
Modeling the functional effect of a mutation is, however, a nontrivial task, due to strong functional interdependencies.
