Sentence examples for functional downstream from inspiring English sources

On the basis of a series of gain-of-function and loss-of-function studies in vitro, we identified FBXW7 as a functional downstream target of miR-223.

These results indicate that, in response to DNA damage, pol η may act as a functional downstream target of FANCD2 and thus, at least partly, mediate FANCD2 function in maintaining chromosomal stability.

Most importantly, Dis3l2 is required for local proliferation, suggesting that Dis3l2 may be a functional downstream gene of Fir1 (Fig. 5B and 5C).

However, methods to capture cells for functional downstream analyses are limited due to inaccessibility of the captured sample or labeling techniques that may be prohibitive to cell function.

We propose that PLD1 roles as a membrane docking site for AP2 and that the functional downstream target of PLD1 lipase activity is PLD1 itself.

Functional downstream CDKN1A network.

First, both sets of measurements detected different functional changes downstream of CaSR and thus any non-linearities in the signaling pathways would change the apparent affinity for Ca2+.

Another study reported loss of functional segregation downstream in the thalamus [11], where the neurons were nonspecific and correlated in the parkinsonian state.

However, since some of the genes containing seed sites within the coding region previously had been implicated in cancer, we speculated that these target candidates may also play a functional role downstream miR-145.

A major functional response downstream of the PI3K arm of insulin signal transduction is increased glucose transport mediated by the GLUT4 transporter.

Handling this plethora of data requires an automated SNP prioritization for initial analysis being followed by more focused functional analysis downstream.