Sentence examples for functional disruptions from inspiring English sources

Nonstructural damage results in lengthy functional disruptions and accounted for several billion dollars of losses in 2010 alone (Fierro et al. 2011).

Nonstructural earthquake damage results in extensive repair costs and lengthy functional disruptions, as nonstructural systems comprise the majority of building investment and are essential to building operations.

Low-frequency "off-line" repetitive transcranial magnetic stimulation (rTMS) over the course of several minutes has attained considerable attention as a research tool in cognitive neuroscience due to its ability to induce functional disruptions of brain areas.

Nucleolar functional disruptions have been shown to generate nucleolar stress signaling to p53 [33].

The increased and decreased functional connectivity observed in specific regions might underlie the functional disruptions described in previous studies [14] [17].

Functional disruptions of these receptors may alter intrinsic hippocampal network activity that in turn affects the ability of the hippocampus to engage in information storage.

Mice with functional disruption of DNA methyltransferase 1 (DNMT1) function demonstrate significant genomic hypomethylation in all tissues and develop aggressive T-cell lymphomas with chromosomal instability [4].

Functional disruption of kinases ATR and Chk1, which function to signal a stalled replication fork, as well as deficiency in recombination factors Rad51, BRCA1, and BLM, that act during the recovery of a stalled replication fork, enhances CFS expression, which is consistent with the model that CFS are generated as a result of DNA replication fork stalling.

Given that AQP4 is an important element for BBB function, such a strong phenotype with AQP4 is consistent with BBB functional disruption.

For instance, a single component of a multiprotein complex or pathway may be disrupted at low frequency, but a high cumulative frequency of functional disruption may occur when alterations to individual complex components are simultaneously considered.

48, 51 These observations strongly suggest that, in steady-state hematopoiesis, TET2 limits the function of HSCs such as self-renewal and LTR capacities, and functional disruption of TET2 either by gene-targeting or disease-associated mutations would lead to aberrantly elevated HSC capacities and subsequent amplification of multipotent progenitor/CMP fraction.