Mice with functional disruption of DNA methyltransferase 1 (DNMT1) function demonstrate significant genomic hypomethylation in all tissues and develop aggressive T-cell lymphomas with chromosomal instability [4].
Functional disruption of kinases ATR and Chk1, which function to signal a stalled replication fork, as well as deficiency in recombination factors Rad51, BRCA1, and BLM, that act during the recovery of a stalled replication fork, enhances CFS expression, which is consistent with the model that CFS are generated as a result of DNA replication fork stalling.
Given that AQP4 is an important element for BBB function, such a strong phenotype with AQP4 is consistent with BBB functional disruption.
For instance, a single component of a multiprotein complex or pathway may be disrupted at low frequency, but a high cumulative frequency of functional disruption may occur when alterations to individual complex components are simultaneously considered.
48, 51 These observations strongly suggest that, in steady-state hematopoiesis, TET2 limits the function of HSCs such as self-renewal and LTR capacities, and functional disruption of TET2 either by gene-targeting or disease-associated mutations would lead to aberrantly elevated HSC capacities and subsequent amplification of multipotent progenitor/CMP fraction.
Furthermore, under small earthquake intensities, the thermal power plant with the combined irregularities had higher risk in functional disruption.
The highly specialized architecture of myelinated fibers renders them prone to functional disruption when any of the critical components are deranged.
First, highly conservative replacements of exterior residues, none of which would cause significant functional disruption alone, are combined until roughly one in five have been changed.
Radulescu et al. [26] mentioned that Duncan and Shim [27] demonstrated a functional disruption of cephalic circulation by a spasm of the main artery or of the cervical branches, with no organic lesion itself.
After 7-day incubation, the control leaves from the non-mutated transgenic plants remained green; however, the biallelic mutated leaves became severely wrinkled and yellowed (Figure 1c), confirming the functional disruption of the BEL gene.
One of the earliest and most frequently employed experimental research methods used to investigate brain-behavior relations involves ablation (removing) or lesion (destruction or functional disruption) of brain structures or areas and determining the effects on behavior.
