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As more disease association studies are carried out on the inflammatory region genes, it becomes increasingly important to identify sequences which are potentially important to gene function and regulation so that functional disease associations can be detected.
This questionnaire can distinguish satisfactorily between organic and functional disease.
Rare genetic mutations in these conditions are functional, disease specific, and highly penetrant.
In fact, only one patient in this study had both organic and functional disease.
Most studies on intestinal glutathione focus on oxidative stress reduction without considering functional disease outcome.
Patients diagnosed with IBS are highly likely to have other functional disease and have more surgery than the general population.
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In these episodic functional diseases, in which susceptible brain regions are hyperexcitable, the attacks begin with hypersynchronous neuronal firing[3].
Functional disease-associated variant is prone to under the evolutionary constraint.
Copy number variations (CNVs) represent an important subset of potentially functional disease-associated variation.
These findings and ours suggest that 5' UTRs are important sites to identify functional disease-associated polymorphisms.
Sequencing of all genes in the genome (exome) [ 13, 14] is an alternative approach relying on the hypothesis that functional disease-associated variation resides in the coding regions.
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