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Differences in the extracellular milieu such as the presence of interacting neighbouring cell populations, exposure to proteases or a hypoxic microenvironment contribute to functional developments within MSC populations originating from different tissues, and intracellular conditions such as the expression levels of certain micro RNAs can additionally balance MSC function and fate.
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An alternative explanation could be that the duration of El Paso residency effects on lung function may be due to reduced functional development over time.
Nikolaou, N. & Meyer, M. P. Lamination speeds the functional development of visual circuits.
Mack-Bucher, J.A., Li, J. & Friedrich, R.W. Early functional development of interneurons in the zebrafish olfactory bulb.
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.
Quairiaux, C., Megevand, P., Kiss, J. Z. & Michel, C. M. Functional Development of Large-Scale Sensorimotor Cortical Networks in the Brain.
Hartung, H., Brockmann, M. D., Poschel, B., De Feo, V. & Hanganu-Opatz, I. L. Thalamic and entorhinal network activity differently modulates the functional development of prefrontal hippocampal interactions.
The visual system, for example, requires early visual experience for normal structural and functional development of the visual cortex, which enables form and depth perception.
Quantifying morphological and functional development in children's feet, and thereby establishing development norms is difficult.
Morphologic and functional development of mastication occurs coincidently during these stages.
It can also be used to detect adverse effects on structural and functional development.
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