Sentence examples for functional destabilization from inspiring English sources

These phenotypes can be attributed to functional destabilization of TRAP and CSP but may also include other TSR proteins that mediate sporozoite motility and invasion of hepatocytes, such as TLP and TRSP, respectively10, 30, 31, 47.

These are manifested as a loss of channel stability in the presence of potassium for Kcv (Figure 6) and the functional destabilization of the Kir2.1 conducting state (Figure 7C, E, & G).

This is in agreement with the notion that FMRP dimerization is abolished in a I304N mutant, which causes structural and functional destabilization of the KH2 fold [ 3, 23, 25, 47, 48].

Cancer-specific changes in DNA methylation may play a role in many cellular functions including destabilization of chromatin, promotion of genomic instability, and hypomethylation of repetitive elements, while some changes may play a functional role in deregulation of gene expression [3], [6], [44].

Buffering and/or compensatory mechanisms that counteract this progressive destabilization during functional adaptation are pivotal for protein evolution as well as protein engineering.

Going against the traditional belief, the calculations also confirm that there is no benefit of reshaping the highly flexible binding pocket to allow the ligand to be comfortably accommodated and avoid conflicting orientations of the functional groups, as the destabilization becomes active from other sources.

Like reporter gene assays and cross-linked immuno-precipitation, biotin-linked chromatography is agnostic to whether the functional effect happens via mRNA destabilization or translational inhibition.

Interestingly, the rearrangements observed in specific structural motifs parallel those identified previously in LeuT and are found to culminate in the release of Na+ ion from the functional Na2 site and the destabilization of the substrate in the S1 site.

If the hypothesis of synaptic destabilization by a functional deficiency of pathways involved in GGFs is eventually proven by a comprehensive research program, it will provide a path for the rational design of preventive and therapeutic interventions.

Whether a functional loss of this interaction induces destabilization of kinetochore fibres and a concomitant continued signalling of the mitotic spindle checkpoint still remains to be established.

Surprisingly, we found that, although introduction of ΔF508 into C. elegans PGP-3 leads to post-transcriptional protein destabilization, PGP-3ΔF508 is still functional, as measured by its ability to rescue pgp-1; pgp-3 double mutants (supplementary material Fig. S2).