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Many types of variants have been identified in PGx genes, such as truncating, missense, deletions, duplications (of functional as well as non-functional alleles) and gene conversions, resulting in functional, partially functional (decreased or reduced function) and non-functional (null) alleles.
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Malnutrition can result in compromised immune function, reduced functional status, decreased performance status, and impaired treatment response [ 23- 25].
The strain-rate sensitivity of the porous silver specimens is found to increase with a functional decrease in the filament length scale and increase in porosity.
The minimizer of a subspace energy functional not only provides a search direction along which the KS total energy functional decreases but also gives an optimal "step-length" to move along this search direction.
These curves in the space of maps are (as explained in [147]) the analogue of gradient lines in Morse theory, and the energy functional decreases on these lines.
Functional decrease in the expression of the Wnt antagonist Sost should effectively increase markers of β-catenin/TCF signaling, such as Axin2 and Tcf3.
Indeed a functional decrease may apply to ADHD.
Aging is characterized by a gradual functional decrease of all systems including the kidneys.
Downregulation of RXFP1 may induce a functional decrease in relaxin activity during vasospasm.
*Chi-squared with Yates' continuity correction; **Adjusted for functional decrease and instrumental activities of daily living.
*Chi-squared with Yates' continuity correction; **2-sided Fisher's exact test; ***Adjusted for functional decrease and IADL difficulties.
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