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Functional deactivation of the posteromedial cortex (PMC) seems to be a physiologic process underlying normal memory.
In normal younger subjects there is functional deactivation (decreased activation) in this network during a broad range of cognitively challenging tasks [17].
Loss of physiological functional deactivation in the PMC may have prognostic value in preclinical AD, and could aid in profiling subgroups of MCI subjects at greatest risk for progressive cognitive decline.
Collectively, our data suggest a functional deactivation of both MDCs and PDCs during sepsis.
In sepsis, long-lasting functional deactivation is common to all circulating monocyte and DC subsets.
Similar to classical monocytes, we observed that CD16positive subsets show signs of profound functional deactivation in sepsis.
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Lustig, C. et al. Functional deactivations: change with age and dementia of the Alzheimer type.
Recent cross-sectional fMRI studies have extended these findings by showing that task-related functional PMC deactivation is reduced in AD and MCI [14], [19], [20].
Single-subject functional activation and deactivation maps from BOLD and CBF time series were estimated using the General Linear Model.
McKiernan, K. A., Kaufman, J. N., Kucera-Thompson, J. & Binder, J. R. A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging.
McKiernan, K. A., Kaufman, J. N., Kucera-Thompson, J. & Binder, J. R. A Parametric Manipulation of Factors Affecting Task-induced Deactivation in Functional Neuroimaging.
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