Sentence examples for functional correction from inspiring English sources

Recent data demonstrate promising effects of combining a corrector with a potentiator — an agent that increases the r∆F508-CFTR Cl- channel function — although the level of functional correction by such complementary therapy in CF patients is still far from that of WT-CFTR.

Conclusion: Suspension of the vaginal vault to the proximal uterosacral ligaments combined with site-specific repair of endopelvic fascia defects provides excellent anatomic and functional correction of pelvic organ prolapse in most women.

Histological improvements were accompanied by significant functional correction, as miMYOT-treated animals showed increased muscle weight and improved specific force in the gastrocnemius, which is one of the most severely affected muscles in TgT57I mice and patients with dominant myotilin mutations.

Evidence of this progress is the recent successful functional correction of the immune T and B lymphocyte deficiency in patients with X-linked severe combined immunodeficiency (X-SCID) and adenosine deaminase (ADA -deficient SCID following onco-retrovirus vector ex vivo trADA -deficientautologouSCIDrrow stem cells [Science 296 (2002) 2410; Science 288 (2000) 669; N. Engl. J. Med. 346 (2002) 1185].

This functional correction was associated with an increase in the number of pancreatic islets and with the recovery of the anatomical and numerical distribution of insulin- and glucagon-producing cells inside them.

Further investigation is needed to determine if haematopoietic stem cells (HSCs) generated from the gene corrected iPS cells can be employed for long-term multi-lineage reconstitution of murine models and functional correction of the disease phenotype (i.e. susceptibility to invading microorganisms).

The RMSE values of different types of functional corrections (i.e., DFT1-7, DFT9 and DFT11) are similar.

In both of these applications, the approach is demonstrated to be able to successfully reconstruct functional corrections and yield accurate predictive solutions while providing a measure of model form uncertainties.

These results show that with respect to the benchmark NCIs by the CCSD(T /CBS level of theory, the RMSE values of most DFT methods with functional corrections are <2 kcal/mol, which is apparently better than the methods in which dispersion corrections are not incorporated into the functionals (i.e., DFT8 and DFT10), where the RMSE values are larger than 3 kcal/mol.

Thus, both ESCs and iPSCs effect functional corrections in mdx muscle.

This suggests that the degree of molecular corrections depends on the number of WT ESCs incorporated and confirms our previous observations indicating that a minimal incorporation of ESCs (less than 5%) is insufficient to effect histological and functional corrections in the mdx musculature.